Neuroendocrine Responses of Spinal Manipulation

Measureable changes in the neuro-endocrinal mechanism following spinal manipulation.

This study reviewed 3 mechanism for the effects of Thoracic spinal manipulation on the neuro-endocrine system. These occur:

1. Through segmental level reflexes.

2. By activation of the autonomic nervous system via supraspinal pathways.

3. By activation of the Hypothalamic-Pituatary-Adrenal Axis, and the release of a cascade of hormones. These include CRH, ACTH, Glucocorticoids, and Catecholamine.


Neuroendocrine Response Following a Thoracic Spinal Manipulation in Healthy Men.

Thoracic Spinal Manipulation resulted in an immediate decrease in salivary cortisol concentration and reduced T/C ratio 6 hours after intervention. A pattern of immediate sympathetic excitation was also observed in the Thoracic Spinal Manipulation group.


Changes in biochemical markers following spinal manipulation-a systematic review and meta-analysis

•Various biochemical markers such as substance-P, neurotensin, interleukins and cortisol modulate pain and inflammation.
•Spinal manipulation increases substance-P, neurotensin, oxytocin and can alter various biochemical marker.
•Spinal manipulation therefore may play an important role in pain and or inflammatory disorders.
•Future RCTs targeting symptomatic participants are required to ascertain the clinical importance of such changes.


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