Measureable changes in the neuro-endocrinal mechanism following spinal manipulation.
This study reviewed 3 mechanism for the effects of Thoracic spinal manipulation on the neuro-endocrine system. These occur:
1. Through segmental level reflexes.
2. By activation of the autonomic nervous system via supraspinal pathways.
3. By activation of the Hypothalamic-Pituatary-Adrenal Axis, and the release of a cascade of hormones. These include CRH, ACTH, Glucocorticoids, and Catecholamine.
Neuroendocrine Response Following a Thoracic Spinal Manipulation in Healthy Men.
Thoracic Spinal Manipulation resulted in an immediate decrease in salivary cortisol concentration and reduced T/C ratio 6 hours after intervention. A pattern of immediate sympathetic excitation was also observed in the Thoracic Spinal Manipulation group.
Changes in biochemical markers following spinal manipulation-a systematic review and meta-analysis
- •Various biochemical markers such as substance-P, neurotensin, interleukins and cortisol modulate pain and inflammation.
- •Spinal manipulation increases substance-P, neurotensin, oxytocin and can alter various biochemical marker.
- •Spinal manipulation therefore may play an important role in pain and or inflammatory disorders.
- •Future RCTs targeting symptomatic participants are required to ascertain the clinical importance of such changes.